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Mild Alzheimer's clinical study

Help advance treatments for Alzheimer’s. Helping you and helping others.

Who is leading this study?

Monash University and Epworth Hospital

This trial is being led by Professor Kate Hoy, from the Monash University Department of Psychiatry in collaboration with the Epworth Hospital in Melbourne.

Complete the questionnaire to see if you qualify

What’s this study about?

The Transcranial Alternating Current Stimulation (tACS) for mild Alzheimer’s clinical trial is an interventional study undertaken by the Epworth Centre for Innovation in Mental Health (ECIMH) to investigate the efficacy of Transcranial Alternating Current Stimulation (tACS) as a treatment for the thinking and memory difficulties in mild Alzheimer’s. Emerging research from neuroscientists around the world has pointed to the potential of harnessing similar brain stimulation technologies to improve cognitive functions. This has been seen as promising as the use of drugs to manage Alzheimer’s has been shown to be limited.

With contributions from trial participants, the findings from this study will help pave the way for more safe and effective treatments for Alzheimer’s. This will help others living with Alzheimer’s maintain their quality of life and improve the medical care given to future generations.

What is Transcranial Alternating Current Stimulation (tACS)?

tACS is a gentle, non-invasive brain stimulation technique which delivers a series of small, pulsed, alternating currents to a targeted region of the brain. This gentle electrical stimulation can change brain activity. While tACS may cause some discomfort, it should not be painful. In this trial, tACS is self-administered (which means you can operate the tACS equipment yourself) in the comfort of your own home, following comprehensive training by a trained researcher.

Am I eligible?

Men and women between 50-85 years of age, who have a diagnosis of mild Alzheimer’s disease, and have frequent contact with a caregiver are able to express an interest to participate in the study.

What participation involves

Participation in this trial involves:
  • Clinical interview, including questionnaires about your thinking, memory and daily activities, which can be completed remotely
  • A minimum of two visits to ECIMH (in Camberwell, Melbourne)
    • The first visit is typically takes 3-4 hours and involves:
      • Electroencephalography (EEG) and cognitive assessments (e.g. memory)
      • Training by a researcher on how to self-administer tACS treatment
      • Provision of first treatment
    • The last visit is generally shorter, taking about 2 hours and involves
      • EEG
  • Four weeks of tACS treatment, once a day Monday to Friday, at home.
    • Set-up, treatment and pack-up should take a total of 40-45 minutes
  • Two follow-up appointments (6 weeks after the end of treatment course and 3 months after the end of the treatment course) which can be conducted remotely over video call.

We would like to know more about how you manage your condition. This short questionnaire will help us to match you to other trials and studies in this area, and to help researchers better understand the condition.

Enrollment into trial

Can be conducted remotely

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Complete the questionnaire to see if you qualify